Supplemental Figure S7.
Next-generation sequencing (NGS) clonality detection in common B-cell lymphomas. Comparison of NGS clonality detection in common B-cell lymphomas in this study compared with previously published results using BIOMED-2 primers (Report of the BIOMED-2 Concerted Action BHM4-CT98-3936).7 In all B-cell malignancy subsets, except mantle cell lymphoma (MCL), the detection rate of the NGS assay with FR1 and leader primers alone surpasses the detection of standardized assays using BIOMED-2 primers targeting FR1, FR2, and FR3 combined. In MCL, the detection is 100% for both. CLL, chronic lymphocytic leukemia; DLBCL, diffuse large B-cell lymphoma; FL, follicular lymphoma; MZL, marginal zone lymphoma; SLL, small lymphocytic lymphoma.