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. 2019 Mar 27;7(6):e14017. doi: 10.14814/phy2.14017

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© 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Median (and IQR) concentration of sulfate during cooling (A) and recovery (B). Measurements at four different time points during a standardized cooling and recovery experiment in healthy controls (n = 10 at all time points), primary Raynaud (n = 10 during cooling, n = 9·10 min after start recovery and n = 8 at the end of recovery) and systemic sclerosis patients (n = 10 during cooling and 10 min after start recovery, n = 9 at the end of recovery). During cooling: HC: Δ = 10.80 [5.25–9.55]; PRP: Δ = 4.45 [2.35–13.28]; SSc: Δ = 1.25 [3.93–0.95]. During recovery: HC Δ = −10.70 [−8.42 to −11.65]; PRP Δ = 5.55 [6.09 to −7.29]; SSc Δ = −10.50 [−22.95–11.25].