Table 1.
Studies of neutrophil subpopulations.
| Neutrophil subsets | Findings | References |
|---|---|---|
| MRSA MOUSE MODEL OF INFECTION | ||
| PMN-I (MRSA - resistant host) | CD49d+/CD11b− | (52) |
| IL-12 and CCL3 production | ||
| Classically activated macrophages | ||
| Expression of TLR2, TLR4, TLR5, TLR8 | ||
| Multi-lobular nucleus | ||
| PMN-II (MRSA-sensitive hosts) | CD49d−/CD11b+ | |
| IL-10 and CCL2 production | ||
| Alternatively activated macrophages | ||
| Expression of TLR2, TLR4, TLR7, TLR9 | ||
| Ring-shaped nucleus | ||
| PMN-N (normal host) | CD49d−/CD11b− | |
| No production of cytokines and chemokines | ||
| No effect on macrophage activation | ||
| Expression of TLR2, TLR4, TLR9 | ||
| Round nucleus | ||
| HEALTHY VOLUNTEERS CHALLENGE WITH I.V. LPS | ||
| CD16bright/CD62Ldim | Not found in healthy donors | (53) |
| Hypersegmented neutrophils | (54) | |
| Rapid apoptosis rate (similar to normal) | (44) | |
| Higher expression of CD11b, CD11c and CD54 | ||
| Inhibit T cell proliferation | ||
| Normal phagocytosis | ||
| Poor capacity to contain intracellular bacteria | ||
| Less chemotactic rate | ||
| Decreased adhesion | ||
| CD16dim/CD62Lbright | Not found in healthy donors | |
| Banded neutrophils | ||
| Higher rate of survival | ||
| Higher NADPH oxidase activity | ||
| Higher acidification of phagosome | ||
| Contain intracellular bacteria | ||
| Enhanced adhesion | ||
| Higher chemotactic rate | ||
| CD16bright/CD62Lbrigh | Phenotypically mature (normal) | |
| TUMOR ASSOCIATED NEUTROPHILS (TANS) | ||
| N1 | Pro-inflammatory properties | (55) |
| TNF production | (56) | |
| High tumoral cytotoxicity | (57) | |
| High NET production | ||
| ICAM1high | ||
| Hypersegmented nucleus | ||
| N2 | Anti-inflammatory | |
| High production of arginase | ||
| Immature-like or segmented nuclei | ||
| Proangiogenic profile | ||
| Higher production of MMP-9 and VEGF | ||
MRSA, methicillin-resistant Staphylococcus aureus.