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. 2019 Mar 20;10:160. doi: 10.3389/fendo.2019.00160

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Copyright © 2019 Dunk, Kwan, Hazan, Walker, Wright, Harris, Jones, Keating, Kingdom, Whittle, Maxwell and Lye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Failed uterovascular transformation in IUGR is associated with the presence of apoptotic mural EVT. Immunohistochemical staining for cytokeratin 7 (CK7, Column 1) and Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL, Column 2) was perfomed to confirm that the fragmented mural EVT that we observed in the IUGR cases were apoptotic. Representative serial sections of control (n = 2/15) and IUGR PBBx (n = 2/8) uterine spiral arteries at the decidual myometrial junction are shown. Arrows indicate the TUNEL positively nuclei of the mural EVT (mEVT) showing cytokeratin loss in the matching serial sections in the IUGR samples. No TUNEL staining was seen in the interstitial EVT (inEVT) of the IUGR cases or any of the EVT populations of the control term samples. Scale bars: black = 50 μM, 100x magnification; red = 20 μM, 200x.magnification.