Table 1.
Diagnostic performance of CA125, HE4 and combination of CA125 + HE4 in the subset of studies cited in this article
| Systematic review or meta-analysis | CA125 | HE4 | CA125 + HE4 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Se (%) (95% IC) | Sp (%) (95% IC) | PPV (%) | NPV (%) | AUC (95% IC) | Se (%) (95% IC) | Sp (%) (95% IC) | PPV (%) | NPV (%) | AUC (95% IC) | Se (%) (95% IC) | Sp (%) (95% IC) | PPV (%) | NPV (%) | AUC (95% IC) | ||
| Ferraro et al. [14] | X | 79 (77–82) | 78 (76–80) | 79 (76–81) | 93 (92–94) | 82 (78–86) | 76 (72–80) | |||||||||
| Dikmen et al. [15] | 63 | 0.78 | 78 | 0.93 | ||||||||||||
| Chen et al. [19] | 93 | 67 | 0.93 (0.88–.97) | 73 | 99 | 0.96 (0.93–1) | 97 | 66 | 0.96 (0.93–1) | |||||||
| Yanaranop et al. [31] | 84 | 53 | 41 | 89 | 0.81 (0.74–0.87) | 66 | 86 | 65 | 87 | 0.82 (0.76–.89) | ||||||
| Wilailak et al. [32] | 0.87 (0.80–0.93) | 0.89 (0.84–0.95) | 0.89 (0.84–0.95) | |||||||||||||
| Wang et al. [36] | X | 79 (74–84) | 82 (77–87) | 0.87 (0.84–0.90) | 76 (72–80) | 94 (90–96) | 0.89 (0.86–0.92) | |||||||||
| Zhen et al. [37] | X | 74 (72–76) | 83 (81–84) | 0.85 | 74 (72–76) | 90 (89–91) | 0.89 | |||||||||
| Abdel-Azeez et al. [45] | 73 (57–86) | 79 (58–93) | 0.90 (0.82–0.97) | 83 (68–93) | 88 (68–97) | 0.95 (0.90–1) | 90 | 79 | ||||||||
| Holcomb et al. [46] | 85 (69–95) | 59 (52–66) | 27 | 96 | 65 (46–80) | 92 (87–95) | 58 | 94 | 91 | 55 | 26 | 97 | ||||
| Moore et al. [48] | 61 | 0.84 (0.77–0.90) | 78 | 0.91 (0.86–0.95) | 81 | 0.91 (0.87–0.96) | ||||||||||
| Goff et al. [52] | 79 (67–88) | 76 (68–83) | 63 | 87 | 58 (45–70) | 94 (88–97) | 83 | 81 | ||||||||
| Meys et al. [55] | X | |||||||||||||||
| Van Gorp et al. [56] | 80 (72–85) | 82 (76–86) | 75 (67–81) | 83 (78–88) | ||||||||||||
| Al Musalhi et al. [57] | 79 | 62 | 38 | 91 | 0.81 | 71 | 90 | 68 | 91 | 0.82 | ||||||
| Moore et al. [62] | 89 (85–93) | 75 (70–79) | 60 | 94 | ||||||||||||
| Li et al. [64] | X | 77 (58–89) | 84 (76–90) | 0.88 (0.85–0.91) | 79 (74–84) | 93 (87–96) | 0.82 (0.78–0.85) | |||||||||
| Wei et al. [66] | 85 | 92 | 91 | 89 | 75 | 98 | 96 | 85 | ||||||||
| Sandri et al. [67] | 91 | 71 | 0.90 (0.86–0.93) | 83 | 91 | 0.92 (0.89–.95) | ||||||||||
CA125 carbohydrate antigen 125, HE4 human epididymis protein 4, Se sensitivity, Sp specificity, PPV positive predictive value, NPV negative predictive value, AUC area under the curve