Table 5.

Summary table of literature analysis, PICOT question 3: influence of smoking on asthma outcomes in patients receiving ICS therapy

Reference	Statement	Type of data source	Final level of evidence (see Fig. 1)	Possible impact on clinical practice (TF opinion)	Similar evidence available from RCTs
Brusselle et al. [33]	Lower asthma control in smokers but same treatment benefit irrespective of smoking status	PC	Low (see text)	No	No
Roche et al. [65]	Better outcomes with extra-fine versus standard size particle ICS, larger differences in current and ex-smokers	D-M-A	Moderate	Uncertain (exploratory)	No