Table 6.

Summary table of literature analysis, PICOT question 4: influence of ICS particle size on asthma outcomes

Reference	Statement	Type of data source	Final level of evidence (see Fig. 1)	Possible impact on clinical practice (TF opinion)	Similar evidence available from RCTs
Van Aalderen et al. [67]	See Table 7	D-M-A	Moderate	Yes	No
Martin et al. [68]	See Table 7	D-M-A	Moderate	Yes	No
Colice et al. [69]	See Table 7	D-M-A	Moderate	Yes	No
Price et al. [70]	See Table 7	D-M-A	Moderate	Yes	No
Price et al. [71]	See Table 7	D-M-A	Moderate	Yes	No
Barnes et al. [40]	See Table 7	D-M-A	Moderate	Yes	No
Price et al. [32]	See Table 7	D-M-A	Moderate	Yes	No
Allegra et al. [72]		PC-A	Low (selection bias, secondary objective)	No	No