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. 2019 Mar 26;17:67. doi: 10.1186/s12916-019-1298-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Network plots of evidence for primary and secondary outcomes: each line links the treatments that have been directly compared in studies. The thickness of the line is proportional to the precision of each direct estimate, and the width of each circle is proportional to the number of studies included in the treatment. The number of studies per comparison is reported next to each line, and the number of patients included in each treatment is reported in the bracket below the treatment name