Table 1.
Effects of OVX and sclerostin antibody on serum sclerostin and bone biomarkers in the three groups of rabbits.
| Sham + vehicle (n = 14) | OVX + vehicle (n = 12) | OVX + Scl-Ab (n = 13) | |
|---|---|---|---|
| Sclerostin (pg/ml) | 31.5 ± 5.8 | 40.9 ± 6.7a | 33.6 ± 5.5b |
| CTX-I (ng/ml) | 31.5 ± 5.8 | 40.9 ± 6.7a | 33.6 ± 5.5b |
| BSAP (mIU/ml) | 9.8 ± 1.1 | 7.9 ± 1.2a | 9.1 ± 1.3b |
BSAP, bone-specific alkaline phosphatase; CTX-I, C-telopeptide of type 1 collagen cross-links; OVX, ovariectomy; Scl-Ab, sclerostin antibody; Sham, sham-operation. Data are expressed as mean ± SD.
a
P < 0.05 comparison with the sham controls and
b
P < 0.05 comparison with the OVX controls analyzed by one-way ANOVA with the Bonferroni post-hoc test. No significant differences were observed between the sham controls and OVX + Scl-Ab.