Table 2.
Effects of OVX and sclerostin antibody on bone mass and microstructure in the three groups of rabbits.
| Sham + vehicle (n = 14) | OVX + vehicle (n = 12) | OVX + Scl-Ab (n = 13) | |
|---|---|---|---|
| Femur BMD (g/cm2) | 358 ± 35 | 326 ± 28a | 350 ± 37b |
| L5 vertebrae BMD (g/cm2) | 298 ± 39 | 260 ± 35a | 286 ± 33b |
| BV/TV (%) | 32.1 ± 5.3 | 23.3 ± 4.5a | 30.1 ± 5.0b |
| Tb.Sp (μm) | 220 ± 61 | 389 ± 80a | 262 ± 72b |
| Tb.Th (μm) | 125 ± 21 | 103 ± 19a | 119 ± 17b |
| Tb.N (1/mm) | 3.01 ± 0.69 | 1.98 ± 0.58a | 2.78 ± 0.62b |
| SMI | 0.82 ± 0.18 | 1.51 ± 0.35a | 0.95 ± 0.31b |
BMD, bone mineral density; BV/TV, Bone volume/total volume; OVX, ovariectomy; Scl-Ab, sclerostin antibody; Sham, sham-operation; SMI, structure model index; Tb.N, trabecular number; Tb.Sp, trabecular separation; Tb.Th, trabecular thickness. Data are expressed as mean , SD.
a
P < 0.05 comparison with the Sham controls and
b
P < 0.05 comparison with the OVX controls analyzed by one-way ANOVA with the Bonferroni post-hoc test. No significant differences were observed between the sham controls and OVX + Scl-Ab.