Table 3.
Scl-Ab treatment rescued marrow adipocyte accumulation in OVX rabbits.
| Sham + vehicle (n = 14) | OVX + vehicle (n = 12) | OVX + Scl-Ab (n = 13) | |
|---|---|---|---|
| Adipocyte mean diameter (μm) | 21.2 ± 3.0 | 30.3 ± 3.5a | 22.4 ± 3.2b |
| Adipocyte density (1/mm2) | 82 ± 25 | 138 ± 34a | 85 ± 23b |
| Percentage of adipocyte area (%) | 26.8 ± 8.2 | 55.9 ± 11.3a | 27.9 ± 8.0b |
OVX, ovariectomy; Scl-Ab, sclerostin antibody; Sham, sham-operation. Data are expressed as mean ± SD.
a
P < 0.001 comparison with the Sham controls and
b
P < 0.001 comparison with the OVX controls analyzed by one-way ANOVA with the Bonferroni post-hoc test. No significant differences were observed between the sham controls and OVX + Scl-Ab.