TABLE 3.

Cox proportional hazards model of the primary composite endpoint

Parameter	Univariable HR (95% CI)	P-value	Multivariable HR (95% CI)	P-value
Subclinical Inflammation (vs NOMOA)	4.13 (1.96, 8.72)	<.001	2.89 (1.27, 6.57)	.01
DSA during year-1 posttransplant (vs no DSA)	3.87 (1.60, 9.35)	.003	3.14 (1.17, 8.39)	.02
Total HLA mismatch (per no. out of 10 possible)	1.18 (0.83, 1.68)	.37
Nonadherence <6 mo posttransplant (yes vs no)	2.04 (0.87, 4.77)	.10	2.34 (0.93, 5.89)	.07
Age at transplant (per year)	1.01 (0.94, 1.08)	.85
Cold ischemia time (per hour)	1.00 (0.99, 1.00)	.66
Black race (vs nonblack race)	2.43 (1.16, 5.10)	.02	1.88 (0.72, 4.90)	.20
Deceased donor (vs living donor)	2.56 (0.98, 6.70)	.06	0.75 (0.18, 3.11)	.69
Male sex (vs female sex)	0.78 (0.37, 1.64)	.52

The primary exposure was subclinical inflammation, defined as either borderline or subclinical T cell–mediated rejection. Covariates that were significantly associated with the primary endpoint at P < .10 by univariable analysis were entered into a multivariable model using forced entry. The final model was significant at P < .001, df = 6, χ² = 29.59.

CI, confidence interval; DSA, donor-specific antibodies; HR, hazard ratio; NOMOA, no major abnormalities.