Table 3.
IVF cycle characteristics and outcomes with subjects divided into four groups by maternal and paternal age
| Variable | Group 1 | Group 2 | Group 3 | Group 4 | p-value |
|---|---|---|---|---|---|
| No. of cycles | 58 | 12 | 37 | 68 | |
| Average maternal age (yr) | 32.0 ± 1.8 | 33.42 ± 0.8 | 36.9 ± 1.9 | 39.3 ± 2.4 | < 0.001 |
| Average paternal age (yr) | 34.5 ± 2.4 | 40.83 ± 2.4 | 36.6 ± 1.9 | 43.4 ± 4.0 | < 0.001 |
| Average difference: paternal–maternal age (yr) | 2.6 ± 2.2 | 7.42 ± 2.5 | –0.3 ± 2.7 | 2.9 ± 2.1 | < 0.001 |
| BMI (kg/m2) | 21.1 ± 3.6 | 22.48 ± 4.2 | 21.1 ± 2.6 | 21.1 ± 3.1 | 0.55 |
| No. of previous IVF attempts | 2.0 ± 1.3 | 2.83 ± 5.7 | 2.1 ± 1.4 | 2.9 ± 2.1 | 0.11 |
| AMH concentration (ng/mL) | 4.7 ± 3.3 | 4.31 ± 2.5 | 4.1 ± 3.4 | 5.3 ± 4.9 | 0.80 |
| Antral follicle count | 16.3 ± 7.4 | 13.83 ± 11.0 | 13.4 ± 6.5 | 14.2 ± 9.5 | 0.18 |
| Basal E2 concentration (pg/mL) | 44.3 ± 24.8 | 35.37 ± 13.7 | 43.4 ± 17.3 | 52.8 ± 36.9 | 0.22 |
| Basal LH concentration (mIU/mL) | 5.0 ± 2.0 | 6.68 ± 3.5 | 5.2 ± 2.6 | 5.3 ± 3.0 | 0.30 |
| Basal FSH concentration (mIU/mL) | 6.5 ± 2.4 | 6.67 ± 1.3 | 6.8 ± 2.2 | 6.4 ± 2.4 | 0.69 |
| E2 concentration on hCG day (pg/mL) | 3,614.2 ± 1,802.8 | 4,416.1 ± 2,502.6 | 3,332.3 ± 1,993.6 | 3,566.8 ± 2,714.5 | 0.67 |
| LH concentration on hCG day (mIU/mL) | 2.9 ± 2.4 | 3.84 ± 3.3 | 2.3 ± 2.3 | 3.7 ± 4.2 | 0.38 |
| Progesterone concentration on hCG day (ng/mL) | 1.0 ± 0.5 | 1.12 ± 0.6 | 0.9 ± 0.7 | 1.0 ± 0.5 | 0.95 |
| Average endometrial thickness on hCG day (cm) | 1.0 ± 0.2 | 1.05 ± 0.3 | 1.0 ± 0.2 | 0.9 ± 0.2 | 0.07 |
| No. of total oocytes | 18.6 ± 10.9 | 18.5 ± 8.6 | 15.9 ± 7.4 | 15.7 ± 11.0 | 0.29 |
| Fertilized oocyte (%) | 67.7 | 70.7 | 71 | 74.3 | 0.39 |
| No. of blastocysts analyzed for PGS | 210 | 36 | 129 | 196 | - |
| Euploid blastocyst | 47.6 (100/210) | 47.2 (17/36) | 35.7 (46/129) | 28.6 (56/196) | 0.001 |
| Abortion rate | 2.4 (1/41) | 0 (0/8) | 20.0 (4/20) | 18.4 (7/38) | - |
| Clinical pregnancy rate | 51.2 (21/41) | 37.5 (3/8) | 65.0 (13/20) | 44.7 (17/38) | 0.44 |
Values are presented as mean±standard deviation or percent (number) unless otherwise indicated. Group 1: maternal age (MA) <35 year, paternal age (PA) ≤38 year; Group 2: MA <35 year, PA >38 year; Group 3: MA ≥35 year, PA ≤38 year; Group 4: MA ≥35 year, PA >38 year.
IVF, in vitro fertilization; BMI, body mass index; AMH, anti-Müllerian hormone; E2, estradiol; LH, luteinizing hormone; FSH, follicle-stimulating hormone; hCG, human chorionic gonadotropin; PGS, preimplantation genetic screening.