Table 1.

GABAergic and VDCC components described in cells of the immune system.

Acronym	Full name	Function	Expressing cells	Species	References
GAD	Glutamate decarboxylase	GABA synthesis	DC, T cell, microglia	Human, mouse	Dionisio et al., 2011; Fuks et al., 2012; Bhandage et al., 2019
GABA-T	GABA-transaminase	GABA degradation	T cell, microglia	Human, mouse	Dionisio et al., 2011; Bhandage et al., 2019
GAT	GABA transporter	GABA transportation across the cell membrane for secretion	DC, microglia, T cell	Human, mouse	Dionisio et al., 2011; Fuks et al., 2012; Bhandage et al., 2019
GABA-A R	GABA-A receptors	Polarization/depolarization of the cell membrane via Cl− flux into/out of the cell	DC, PBMCa, T cell, monocyte, macrophage, microglia	Human, mouse, rat	Tian et al., 2004; Bhat et al., 2010; Dionisio et al., 2011; Wheeler et al., 2011; Fuks et al., 2012; Mendu et al., 2012; Bhandage et al., 2015, 2018a, 2019
NKCC	Na+-K+-Cl− co-transporter	GABA-A R regulation via Cl− transport into the cell	PBMC, microglia	Human, mouse	Bhandage et al., 2015, 2018a, 2019
KCC	K+-Cl− co-transporter	GABA-A R regulation via Cl− transport out of the cell	PBMC, microglia	Human, mouse	Bhandage et al., 2015, 2018a, 2019
VDCC (CaV)	Voltage-dependent calcium channels	Ca2+ signaling via flux into/out of the cell	DC, PBMC, microglia	Human, mouse	Kanatani et al., 2017; Bhandage et al., 2018b, 2019

^aperipheral blood mononuclear cells.