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Comparison of the resistance of warfarin (6) and COT-warfarin (8) against the 27 naturally occurring VKOR mutants. The potency of warfarin and COT-warfarin (8) on VKOR activity inhibition expressed as IC50 (concentrations required for 50% inhibition of VKOR activity) and normalized (resistance for wild-type VKOR is normalized as 1).
