Figure 3.

ChABC in Sucr 2.5 mol/L improved hindlimbs locomotor function (BBB scale) and C4S degradation. A, Experimental design showing intraspinal injections into the gliotic scar of ChABC in Sucr 2.5 mol/L at the depth of 100 μm (see methods for details). B, Each animal was subjected to treadmill training. Results point out that at 6 wk after contusion, 2 wk after ChABC treatment, treated animals showed significantly higher BBB score compared to control group (P**<.01 control vs treated) and compared to ChABC (Sal) group (P*<.05 ChABC (Sal) vs ChABC (Sucr 2.5 mol/L) C, quantification of C4S degradation reveals a significant digestion at the epicenter of injury following ChABC (Sucr 2.5 mol/L) treatment (** indicate significant difference compared with both Control and ChABC (Sal); P < .01, one‐way repeated‐measures ANOVA, Tukey's post hoc)