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After injury, fibrin deposits inside the nerve while Schwann cells undergo de-differentiation and upregulate p75NTR. During active phases of regeneration p75NTR expression is diminished in remyelinating Schwann cells, and the induction of the plasminogen and of the tissue plasminogen activator (tPA)/plasmin cascade leads to fibrin degradation thus promoting remyelination. Modified with permission from Akassoglou et al. (2002).
