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. Author manuscript; available in PMC: 2019 Mar 27.
Published in final edited form as: Nat Biomed Eng. 2018 Jul 30;2(12):894–906. doi: 10.1038/s41551-018-0273-3

Figure 1. Illustration of CGM sensing in vivo.

Figure 1.

(a) Non-coated sensor induces inflammatory immune cascade, and the host response causes sensor noise and inaccuracy requiring frequent BG calibrations. The zwitterionic polymer-coated sensor overcomes the hostile in vivo environment, eliminating sensor noise and the requirement for BG re-calibrations. (b) Components of the CGM, including bright-field and SEM images of the CGM electrode. (c) Illustration of the enzymatic mechanism of glucose detection by the electrode. (d) Examples of different zwitterionic copolymer units utilized for constructing biomaterial combinatorial library. (e) Biocompatibility (inflammation profile) results from the zwitterionic biomaterial library screen. The combinatorial library contained 64 various zwitterionic polymer hydrogels using four-arm PEG polymers (2kDa or 5kDa) as crosslinkers. Note: inversion of monomers (ie., CB1-SB1 and SB1-CB1) indicates have the same polymeric structure with different mole ratios of the monomers (See supplement for further elaboration). Experiments repeated at least 2–3 times.