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. Author manuscript; available in PMC: 2019 Mar 27.
Published in final edited form as: Nat Biomed Eng. 2018 Jul 30;2(12):894–906. doi: 10.1038/s41551-018-0273-3

Figure 5. Sensing performance of CGMs in NHP model.

Figure 5.

(a) Sensor insertion and use of breathable jacket to secure sensors from handling by animals. (b) Linear regression plots of signal versus BG value during 3-day recording periods, for both non-diabetic and diabetic NHPs. (c) Non-recalibrated versus recalibrated (using all measured BG) data for both non-diabetic and diabetic models. (d) Non-recalibrated glucose level versus BG and recalibrated versus BG comparisons for both non-diabetic and diabetic NHPs. (e) and (f) Significance of various comparison methods of (e) non-diabetic and (f) diabetic model (N=3 sensor for each group, and each sensor recording >1000 data points). Data were presented as Mean±SD. Significance was calculated by one-way ANOVA. * p<0.05. (g) Representative histology images (H&E and Trichrome staining) of tissue with subcutaneously-inserted coated and non-coated electrodes in non-diabetic and diabetic NHPs (N=2–3 animals/health state; from each of which 24 sensors total (3 rounds of 4 controls and 4 coated) were collected).