Table IV.
Studies on polymorphisms of apolipoprotein E (ApoE) and brain-derived neurotrophic factor (BDNF) and focal epilepsy.
| First Author | Gene, specific polymorphism | Epilepsy type | Type of study | Number of patients and control group | Statistics and P-value |
|---|---|---|---|---|---|
| Blumcke [43] | Apo E | TLE with or without Ammons horn sclerosis (AHS) | Genetic linkage study | 125 patients (65 TLE-AHS+, 53 TLE-AHS−) | NS |
| Gambardella [44] | Apo E −491 A/T |
Non-lesional TLE | Case- control | 63 patients, 220 controls | NS |
| Yeni [45] | Apo E4 | Mesial TLE–HS | Case- control | 47 cases, 62 controls | OR=1.06 CI=0.38–2.95 p>0.05 |
| Briellmann [46] | ApoE4 | Chronic TLE | No controls | 43 patients, 31 HS+ | ApoE4 may have impact on earlier onset of seizures p=0.004 |
| Kanemoto [47] | ProBDNF 240T |
Focal epilepsy | Case- control | 219 cases, 311 controls | X2=8.59 p=0.0034 |
| Lohoff [48] | BDNF C240T Val66Met |
TLE | Case- control | 151 cases, 189 controls | NS |