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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Comput Toxicol. 2019;10:113–129. doi: 10.1016/j.comtox.2019.01.007

Figure 5. Chemical modulation of cholesterogenic and lipogenic genes across time.

Figure 5.

Figure 5.

Figure 5.

The effects of chemical exposure on cholesterogenic and lipogenic genes were examined in the TG-GATES study. (Top panels) The −Log(p-value)s for the correlations between the SREBP biomarker and the indicated treatment. (Bottom panels) Effects of treatment on lipogenic and cholesterogenic genes is shown (see legend to Figure 4).

A. Chemicals that exhibited transient and early suppression of SREBP.

B. Activators of PPARα. The activation of PPARα is also shown as assessed using a gene expression biomarker that was characterized earlier (Rooney et al., 2018b).

C. Chemicals that activated SREBP and caused steatosis.