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. 2018 Dec 31;33(4):4866–4882. doi: 10.1096/fj.201801382R

Figure 3.

Figure 3

Cellular senescence is promoted by the down-regulation of caveolin-1 expression. AC) Caveolin (Cav)-1 expression was down-regulated in WI-38 and IMR-90 fibroblasts by shRNA. Cells expressing scrambled (Scr) shRNA were used as the control. Ten days after the infection, cellular senescence was quantified by SA-β-gal staining. Quantification (A), representative low-magnification images (B) and representative high-magnification images (C) are shown. D) WI-38 and IMR-90 cells were transfected with caveolin-1 siRNA. Transfection with scrambled (Scr) siRNA was used as the control. After 10 d, cellular senescence was quantified by SA-β-gal staining. Values represent means ± sem. *P < 0.001 (Student’s t test).