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Alisertib causes irreversible growth arrest in human fibroblasts. WI-38 fibroblasts were treated with either DMSO or alisertib (16 μM) for 10 d. Cells were then washed and recovered in alisertib-free medium for an additional 5 d. A) Cells were stained for SA-β-gal activity. B) A BrdU-incorporation assay was performed. C) The number of cells in the cell culture dishes was counted. Values represent means ± sem. *P < 0.001, student’s t test.
