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. 2019 Jan 30;33(4):5287–5299. doi: 10.1096/fj.201801110RR

Figure 2.

Figure 2

Characterization of the firing activity of iN networks during development. A) Phase-contrast image of NEUROG2/1 iNs on an MEA on d 14. Scale bar, 30 μm. B) Quantification of the percentage of active electrodes from iN networks at different time points during development. Data were collected from 9 MEAs. P < 0.0001, F(5, 48) = 50.2, 1-way ANOVA. C) Quantification of the mean spike rate from iN networks at different time points during development. Data were collected from 9 MEAs. P < 0.0001, F(5, 766) = 17.82, 1-way ANOVA. D) Representative raster plots show the spontaneous firing activities recorded from iN networks during development. E) Cross correlation analysis of the synchrony of spontaneous firing activities from iN networks on d 20, 25, 30, and 60 after induction. Data were collected from 9 MEAs. Box and whisker plots are used to show the median and the 5th to 95th percentiles. Plus sign indicates the means; 1-way ANOVA, F(3, 3966) = 385.7, P < 0.0001. ****P < 0.0001 Tukey’s multiple comparisons test.