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. 2019 Jan 25;33(4):5654–5666. doi: 10.1096/fj.201802145RR

Figure 3.

Figure 3

Muscle-specific TRB3 overexpression increases food deprivation–induced skeletal muscle atrophy. Ten- to 13-wk-old female TG mice and their WT littermate control mice were used to determine the role of TRB3 in skeletal muscle mass regulation under food deprivation–induced atrophy conditions. A) TRB3 overexpression was confirmed by RT-PCR with increased TRB3 mRNA expression in TA muscles. TG and WT mice were divided into groups with free access to food (Fed) and groups deprived of food for 48 h (FD). B) Percentage change in body weight between Fed and FD groups in both WT and TG mice was determined. C) Percentage of food deprivation–induced atrophy was determined in TA, EDL, SOL, and GAS muscles. A.U., arbitrary unit. Data are the means ± sem (n = 6/group). ***P < 0.001 vs. Fed, #P < 0.05, ##P < 0.01 vs. WT.