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. 2019 Jan 16;33(4):5585–5598. doi: 10.1096/fj.201802056R

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© The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MSCs promote SAEC wound repair in normocapnia but not HCA. Ai, ii) MSCs in a noncontact (Transwell) coculture with SAECs that had been wounded in an in vitro scratch assay promoted SAEC wound closure in normocapnia. This effect was not observed in HCA at 24 h (n = 4 per group). B) Wounded SAECs that had been cultured with MSCs in a noncontact coculture were immunofluorescently stained for the proliferation marker Ki67. Imaging revealed no difference in proliferation across any of the conditions investigated (n = 3 per group). Images were taken by Zeiss Axiovert 25 CFL microscope Ai) Representative images. Aii) Percentage of wound closure over 24 hours was quantified for each condition. Aii, B) Box and whisker plots (Aii) show median, first and third quartiles, and maximum and minimum values; scatter plots (B) show mean and sd. Original magnification, ×20. *P < 0.05.