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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: MRS Commun. 2018 Sep 25;9(1):37–52. doi: 10.1557/mrc.2018.203

Fig. 1. Schematic drawing of the bone marrow niche in vivo.

Fig. 1

The simplified representation of the niche in the bone marrow shows the microenvironment of HSCs (light red) consisting of several types of niche cells such as the OBs (blue) located at the endosteum, perivascular endothelial cells (red) or MSCs (purple) and biochemical stimuli due to the expression of soluble factors (red and yellow dots) by niche cells. Furthermore, biophysical parameters (different stiffnesses reviewed in Nelson & Roy[18]) throughout the bone marrow which have an impact on cells behavior are illustrated in green.