Table 4. Levofloxacin, garenoxacin, sitafloxacin and with gyrA and gyrB mutations.
| Strains | gyrA mutation | gyrB mutation | Levofloxacin | Garenoxacin | Sitafloxacin | |||
|---|---|---|---|---|---|---|---|---|
| MIC | Status | MIC | Status | MIC | Status | |||
| Dominica08 | None | None | 0.25 | S | <0.063 | S | 0.125 | S |
| Dominica32 | None | None | 0.25 | S | 0.125 | S | <0.063 | S |
| Dominica57 | None | None | 0.25 | S | 0.125 | S | <0.063 | S |
| Dominica95 | None | None | 0.25 | S | 0.125 | S | <0.063 | S |
| Dominica9 | None | None | 16 | R | 8 | R | 0.5 | S |
| Dominica10 | N87I | None | 32 | R | 8 | R | 0.5 | S |
| Dominica14 | D91G, E193D, I194F, A197F | None | 2 | R | 1 | R | 0.125 | S |
| Dominica18 | N87T, D91N | None | 16 | R | 8 | R | 0.5 | S |
| Dominica43 | N87T, D91N | None | 2 | R | 0.5 | S | 0.125 | S |
| Dominica44 | N87T, A97V | None | 16 | R | 8 | R | 0.25 | S |
| Dominica49 | N87A | D435N, S479G | 32 | R | 8 | R | 0.5 | S |
| Dominica50 | E58G, G75V, D91G, Q98L | None | 2 | R | 1 | R | 0.125 | S |
| Dominica51 | D91N | None | 2 | R | 1 | R | 0.125 | S |
| Dominica60 | D91Y, A134V, D145N | None | 2 | R | 0.5 | S | <0.063 | S |
| Dominica62 | D91N | S479G | 2 | R | 1 | R | 0.125 | S |
| Dominica71 | N87I | S479G | 32 | R | 8 | R | 0.5 | S |
| Dominica73 | None | None | 32 | R | 4 | R | 0.125 | S |
| Dominica75 | N87I | None | 32 | R | 8 | R | 0.5 | S |
| Dominica96 | None | None | 4 | R | 4 | R | 0.25 | S |
| Dominica103 | N87I, D91N, I162T | None | 16 | R | 8 | R | 0.5 | S |
| Dominica115 | N87K | None | 2 | R | 1 | R | 0.125 | S |
| Dominica142 | N87T, D91N | None | 4 | R | 1 | R | 0.25 | S |
| Dominica146 | N87T | None | 16 | R | 8 | R | 0.25 | S |
| Dominica147 | D91Y | None | 2 | R | 2 | R | 0.125 | S |
| Dominica148 | None | None | 2 | R | 0.25 | S | <0.063 | S |
| Dominica150 | N87T, D91N, F149V | None | 16 | R | 0.25 | S | <0.063 | S |
| Dominica152 | N87I | Y514F | 8 | R | 4 | R | 0.5 | S |
MIC: Minimal Inhibitory Concentration, in μg/mL. S: sensitive; R: resistant. N87I means isoleucine replaced asparagine in amino acid position 182. We ignored mutation that were present in both sensitive and resistant strains.