Table 2:
Association of Patient Characteristics with Direct Acting Antiretroviral (DAA) Adoption
| Unadjusted | Adjusted for Demographics | Fully Adjusted | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Characteristic | OR | 95% CI | p-value | OR | 95% CI | p-value | OR | 95% CI | p-value | |||
| Region | <0.01 | <0.01 | <0.01 | |||||||||
| South-Urban | Ref | Ref | Ref | |||||||||
| Isolated Rural Towns | 0.92 | 0.82 | 1.04 | 0.94 | 0.83 | 1.06 | 0.94 | 0.83 | 1.06 | |||
| Rural Micropolitan | 0.95 | 0.89 | 1.01 | 0.95 | 0.90 | 1.02 | 0.95 | 0.89 | 1.01 | |||
| Small Rural Towns | 0.85 | 0.78 | 0.93 | 0.87 | 0.79 | 0.95 | 0.85 | 0.77 | 0.93 | |||
| Midwest-Urban | 1.12 | 1.08 | 1.15 | 1.12 | 1.08 | 1.15 | 1.15 | 1.12 | 1.19 | |||
| Isolated Rural Towns | 1.24 | 1.10 | 1.40 | 1.28 | 1.13 | 1.44 | 1.27 | 1.12 | 1.44 | |||
| Rural Micropolitan | 1.07 | 0.98 | 1.16 | 1.10 | 1.01 | 1.19 | 1.11 | 1.02 | 1.19 | |||
| Small Rural Towns | 1.22 | 1.09 | 1.37 | 1.26 | 1.13 | 1.42 | 1.27 | 1.13 | 1.43 | |||
| Northeast-Urban | 0.96 | 0.92 | 0.99 | 0.95 | 0.92 | 0.98 | 0.93 | 0.90 | 0.96 | |||
| Isolated Rural Towns | 1.04 | 0.83 | 1.30 | 1.06 | 0.85 | 1.32 | 1.00 | 0.79 | 1.25 | |||
| Rural Micropolitan | 1.10 | 0.94 | 1.28 | 1.12 | 0.96 | 1.31 | 1.07 | 0.91 | 1.25 | |||
| Small Rural Towns | 1.22 | 0.99 | 1.52 | 1.26 | 1.01 | 1.55 | 1.24 | 1.00 | 1.54 | |||
| West-Urban | 0.95 | 0.92 | 0.97 | 0.93 | 0.86 | 1.01 | 1.00 | 0.97 | 1.03 | |||
| Isolated Rural Towns | 1.10 | 0.96 | 1.27 | 1.15 | 1.00 | 1.33 | 1.21 | 1.05 | 1.40 | |||
| Rural Micropolitan | 0.89 | 0.82 | 0.97 | 0.93 | 0.86 | 1.01 | 0.94 | 0.87 | 1.03 | |||
| Small Rural Towns | 0.94 | 0.83 | 1.07 | 0.98 | 0.87 | 1.12 | 1.02 | 0.90 | 1.16 | |||
| Age | 1.005 | 1.00 | 1.01 | <0.01 | 0.999 | 0.997 | 1.001 | 0.42 | ||||
| Female | 0.97 | 0.92 | 1.03 | 0.33 | 0.91 | 0.86 | 0.96 | <0.01 | ||||
| Race | <0.01 | <0.01 | ||||||||||
| White | Ref | Ref | ||||||||||
| Black | 1.07 | 1.04 | 1.09 | 1.09 | 1.07 | 1.12 | ||||||
| Native Hawaiian/Pacific Isl. | 0.90 | 0.77 | 1.05 | 0.87 | 0.74 | 1.03 | ||||||
| American Indian/AK Native | 0.95 | 0.85 | 1.07 | 0.96 | 0.86 | 1.08 | ||||||
| Asian | 0.85 | 0.68 | 1.07 | 0.82 | 0.65 | 1.03 | ||||||
| Mixed Race | 1.08 | 0.95 | 1.22 | 1.08 | 0.95 | 1.22 | ||||||
| Unknown/Other | 0.66 | 0.63 | 0.70 | 0.66 | 0.62 | 0.70 | ||||||
| HCV Complications | ||||||||||||
| FIB4>3.25 | 1.16 | 1.13 | 1.20 | <0.01 | ||||||||
| Cirrhosis | 1.18 | 1.15 | 1.22 | <0.01 | ||||||||
| Hepatocellular Carcinoma | 0.46 | 0.42 | 0.50 | <0.01 | ||||||||
| Liver Transplant | 1.70 | 1.52 | 1.92 | <0.01 | ||||||||
| Prior Treatment Experience | 2.29 | 2.20 | 2.39 | <0.01 | ||||||||
| Comorbid Disease | ||||||||||||
| Diabetes | 0.99 | 0.97 | 1.02 | 0.62 | ||||||||
| BMI>30 kg/m2 | 1.15 | 1.12 | 1.18 | <0.01 | ||||||||
| HIV | 1.37 | 1.29 | 1.46 | <0.01 | ||||||||
| AUDIT C >=4 | 0.72 | 0.70 | 0.74 | <0.01 | ||||||||
| Alcohol Use Dependence | 0.95 | 0.92 | 0.97 | <0.01 | ||||||||
| Substance Use Dependence | 0.83 | 0.81 | 0.85 | <0.01 | ||||||||
| Severe Mental Illness | 1.08 | 1.05 | 1.10 | <0.01 | ||||||||