Figure 2.

Simplified signaling pathways downstream of growth factor signaling. PP2A negatively regulates proliferation and cell survival at multiple nodes. However, PP2A may be inhibited in cells with aberrantly active growth signaling resulting from activating mutations or oncogenic fusion proteins of the receptor tyrosine kinases shown, thereby allowing increased signaling through these pathways and tumorigenic progression. In this setting, simultaneously inhibition of oncogenic kinases and reactivation of PP2A harbors the potential for synergistic antineoplastic effects.