Table 1:
PP2A targeting agents
| PP2A Activating Agent |
Class | Target Protein | Reference(s) |
|---|---|---|---|
| Phenothiazine | Tricyclic neuroleptic | PP2A-A scaffolding subunit | Gutierrez et al. JCI 2014 |
| SMAP | Phenothiazine derivative | PP2A-A scaffolding subunit | Sangodkar et al. JCI 2017 |
| OP449 | SET-targeting peptide | SET | Christensen et al. Blood 2014 |
| FTY720 | Sphingosine analog | SET | Neviani et al. JCI 2007 |
| Forskolin | Diterpene | Unknown | Feschenko et al. J Pharmacol Exp Ther 2002 |
| PP2A Inhibiting Agent | Class | Target Protein | Reference(s) |
| LB100 (LB1.2) | Norcantharidin derivative | PP2A – binding partner unknown | Lu et al. PNAS 2009 |