Skip to main content
. Author manuscript; available in PMC: 2019 Jul 9.
Published in final edited form as: Nature. 2019 Jan 9;565(7740):448–453. doi: 10.1038/s41586-018-0845-0

Figure 5: Greek Island hubs interact specifically with the transcriptionally active OR locus.

Figure 5:

a, Increased contacts between the active OR promoter and Greek Islands located in short range cis (<5Mb, grey), long range cis (>5Mb, blue) and trans (red). Greek Island interactions are expressed as the fraction of the total HiC contacts mapped to each promoter (5 Kb resolution). b, Profile of the OR cluster containing Olfr16 reveals increased contacts, expressed as fraction of the total HiC contacts mapped to each position (5 Kb resolution), between the Olfr16 locus and Greek Islands in Olfr16 expressing cells. c, Manhattan plot of Greek Island contacts with OR genes reveals that in Olfr16+ cells the Olfr16 locus is the OR gene most significantly enriched for Greek Island contacts relative to heterogeneous mOSNs (see Extended Materials and Methods). All panels present pooled data from 2 independent biological replicates that yielded similar results when analyzed separately.