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. Author manuscript; available in PMC: 2020 Apr 1.

Published in final edited form as: Neurobiol Aging. 2018 Dec 21;76:35–44. doi: 10.1016/j.neurobiolaging.2018.12.003

Figure 1. — Volcano plots showing the identified VMPs associated with amyloid plaques (1A) and tangles (1B). The p-values in -log10 scale (Y-axis) are plotted against the log2 fold change (log2FC) of variability with respect to unit increase of the pathological burden (X-axis). A positive log2FC represents hypervariable methylation and a negative log2FC represents hypovariable methylation. The VMPs with q < 0.05 are marked with the blue color and the VMPs with q > 0.05 are marked with red color. The dashed horizontal line represents genome wide significance level α = 3.6 × 10⁻⁸, and the VMPs with < 3.6 × 10⁻⁸ are annotated by genes within ±5kb of the probe.

Figure 1. — Volcano plots showing the identified VMPs associated with amyloid plaques (1A) and tangles (1B). The p-values in -log10 scale (Y-axis) are plotted against the log2 fold change (log2FC) of variability with respect to unit increase of the pathological burden (X-axis). A positive log2FC represents hypervariable methylation and a negative log2FC represents hypovariable methylation. The VMPs with q < 0.05 are marked with the blue color and the VMPs with q > 0.05 are marked with red color. The dashed horizontal line represents genome wide significance level α = 3.6 × 10⁻⁸, and the VMPs with < 3.6 × 10⁻⁸ are annotated by genes within ±5kb of the probe.