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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Neurobiol Aging. 2018 Dec 21;76:35–44. doi: 10.1016/j.neurobiolaging.2018.12.003

Table 4.

Top 30 enriched pathways related to AD neuropathology

Pathway/GO terms q-value*
amyloid-β tangles
Regulation of neuron projection development 3.88×10−12 3.43×10−12
Calcium ion transmembrane transporter activity 2.10×10−9 2.42×10−5
Postsynapse 6.94×10−9 8.00×10−11
Calcium ion transmembrane transport 1.04×10−8 1.16×10−4
Positive regulation of cell projection organization 1.73×10−8 4.03×10−7
Positive regulation of neuron projection development 2.48×10−8 4.07×10−8
Cell leading edge 2.94×10−8 4.22×10−8
Positive regulation of neuron differentiation 8.55×10−8 6.84×10−8
Divalent inorganic cation transmembrane transporter activity 2.71×10−7 1.69×10−3
Calcium ion transport 1.29×10−6 8.72×10−5
Actin binding 1.51×10−6 4.07×10−8
REACTOME: Axon guidance 2.15×10−6 1.19×10−5
Positive regulation of nervous system development 3.77×10−6 4.36×10−7
Cell projection membrane 5.90×10−6 2.04×10−6
Divalent inorganic cation transport 5.90×10−6 6.08×10−4
Regulation of dendrite development 8.98×10−6 1.60×10−4
Gtpase binding 9.91×10−6 6.31×10−5
Synaptic membrane 1.02×10−5 4.07×10−8
Guanyl nucleotide exchange factor activity 1.21×10−5 6.84×10−8
Main axon 1.55×10−5 8.56×10−4
Excitatory synapse 2.39×10−5 2.93×10−9
Regulation of small gtpase mediated signal transduction 2.39×10−5 1.08×10−6
Regulation of cell morphogenesis involved in differentiation 8.82×10−5 4.36×10−7
Cation channel activity 1.17×10−4 1.31×10−6
Neuron porjection morphonenesis 1.31×10−4 4.03×10−7
Axon 1.33×10−4 9.97×10−8
Receptor complex 2.27×10−4 1.50×10−6
Ras guanyl nucleotide exchange factor activity 1.42×10−3 4.36×10−7
Gated channel activity 3.47×10−3 1.06×10−7
Neuronal postsynaptic density 3.99×10−2 1.11×10−6
*

Adjusted for multiple testing by the Benjamini-Hochberg method