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The summed longest diameter of the corneal discs in each group in the first experimental run is shown as a function of time, which has been normalized against the maximum time taken for corneas cross-linked using the standard 0.1% riboflavin formulation (42 days) to undergo complete digestion. The discs appeared to stop digesting at approximately day 26 (normalized time of 0.62) so temperature was increased to 26°C and the digest solution renewed.
