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In this study, it is shown that ICOSL binds podocyte αvβ3 integrin through its RGD motif. Kidney injury results in a rapid increase of ICOSL expression, leading to podocyte protection by blocking active αvβ3 integrin. ICOSL acts as a regulatory brake to modulate active αvβ3 integrin–mediated signaling. Fp, foot process.
