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. 2019 Mar 4;129(4):1626–1640. doi: 10.1172/JCI98288

Figure 7. FL-associated ATP6V1B2 mutations and dependence on autophagic flux for survival of primary FL B cells.

Figure 7

(A and B) Primary human purified FL B cells carrying WT or mutant ATP6V1B2 were cultured in serum-supplemented RPMI 1640 medium containing 100% leucine and treated with the ULK1 inhibitor MRT68921 for 72 hours at the indicated concentrations. Cell viability was measured using CellTiter-Glo and was normalized to the viability of cells cultured for 72 hours but left untreated. *P < 0.05, **P < 0.01, and ***P < 0.001 by t test, compared with results for WT at the same time point. Data represent the SD.