Fig. 1.

Schematic representation of interpretation strategies depicting a common distribution of reference-standard diagnoses for each interpretation strategy. Final diagnostic interpretation and ensuing clinical outcomes are affected by the interpretation strategy’s misclassification rate relative to the reference-standard diagnosis as well as conditional probabilities of over and under-interpretation when a diagnostic misclassification occurs. *The probability of over-interpretation is zero for women with reference-standard diagnosis of invasive cancer. ^**The probability of under-interpretation is zero for women with reference-standard diagnosis of other benign findings