Table 3. Multivariate analysis of maternal reports of infection and physician-notified AEs as a predictor of plasma hepcidin.
| No. of events |
Geometric mean hepcidin (% >5.5 ng/ml) |
F ratio | P* | ||
|
Illness Yes |
Illness No |
||||
| Maternal reports† | |||||
| Any sickness | 341 | 5.43 (45%) | 4.33 (45%) | 8 | 0.0052 |
| Clinical records‡ | |||||
| AEs | 425 | 6.19 (59%) | 4.23 (44%) | 31 | <0.0001 |
| Fever | 154 | 7.50 (68%) | 4.30 (44%) | 26 | <0.0001 |
| Diarrhea | 129 | 4.95 (49%) | 4.37 (45%) | 1 | NS |
| Respiratory | 154 | 6.92 (64%) | 4.31 (44%) | 19 | <0.0001 |
| Skin | 114 | 5.41 (54%) | 4.36 (45%) | 3 | 0.09 |
*P values obtained from multilevel linear modeling included subject, treatment group, and time as covariates.
†Number of reported illnesses at twice weekly fieldworker visits coinciding with hepcidin measurements (total n = 5113).
‡Number of recorded AEs coinciding with hepcidin measurements ±4 days (total n = 5113).