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. 2019 Mar 27;5(3):eaav1118. doi: 10.1126/sciadv.aav1118

Fig. 4. SIRT7 is required for DNA damage repair.

Fig. 4

(A) HCT116 cells were transfected with the indicated siRNAs and irradiated at 10 Gy and released for the indicated time periods. Total cell lysates were subjected to immunoblotting analysis. (B) WT or SIRT7 KO (1# and 2#) cells were subjected to colony formation assay. All data represent the means ± SD. (C) WT or SIRT7 KO (1#) cells were subjected to comet assay. The original representative images were shown on the left panel. All data represent the means ± SD. (D and E) DR-U2OS and pEJ5-U2OS cells were transfected with the indicated plasmids or siRNAs and subjected to HR and NHEJ assays, respectively. All data represent the means ± SD.