TABLE III.

Results of the NLME and two-stage approaches

Parameter	Variable	NLME			Two-stage approach
		Estimate (× 10−3)	Std.Error (× 10−3)	p-value	Estimate (×10−3)	Std.Error (×10−3)	p-value
K1	AE - Control	−6.182	4.023	0.125	−6.821	4.167	0.105
	NRM - Control	5.415	4.179	0.195	3.827	4.235	0.369
	Male - Female	−8.232	3.302	0.013	−7.028	3.407	0.042
	Age (1 year diff.)	−0.021	0.120	0.858	−0.035	0.126	0.783
k2	AE - Control	7.863	7.956	0.323	−1.502	11.690	0.898
	NRM - Control	14.148	8.697	0.104	2.240	11.882	0.851
	Male - Female	−14.756	6.544	0.024	−11.014	9.557	0.252
	Age (1 year diff.)	0.115	0.213	0.589	0.015	0.352	0.965
k3	AE - Control	−1.909	2.450	0.436	−3.728	3.433	0.280
	NRM - Control	2.180	2.679	0.416	0.697	3.489	0.842
	Male - Female	−2.427	2.073	0.242	−2.084	2.807	0.460
	Age (1 year diff.)	−0.145	0.065	0.025	−0.121	0.104	0.244
k4	AE - Control	−0.022	0.968	0.982	−0.130	1.331	0.922
	NRM - Control	−0.544	0.963	0.572	−0.476	1.353	0.726
	Male - Female	0.501	0.777	0.520	0.536	1.088	0.624
	Age (1 year diff.)	0.031	0.026	0.236	0.063	0.040	0.123
VND	AE - Control	−46.093	25.715	0.076	−41.397	26.081	0.116
	NRM - Control	1.819	26.138	0.945	9.783	26.510	0.713
	Male - Female	−29.146	21.024	0.169	−27.244	21.323	0.205
	Age (1 year diff.)	−0.396	0.775	0.611	−0.218	0.786	0.782
VT	AE - Control	−199.169	94.978	0.039	−4509.015	5484.074	0.413
	NRM - Control	64.530	96.539	0.506	−3983.753	5574.219	0.477
	Male - Female	−165.526	77.651	0.036	−4190.468	4483.598	0.352
	Age (1 year diff.)	−4.699	2.864	0.104	62.156	165.370	0.708
BPND	AE - Control	−103.513	43.309	0.019	−21594.627	27 285.339	0.431
	NRM - Control	180.970	44.021	<0.001	−20 077.763	27 733.845	0.471
	Male - Female	−193.907	35.408	<0.001	−20 251.287	22 307.596	0.366
	Age (1 year diff.)	−11.674	1.306	<0.001	320.045	822.780	0.698
BPP	AE - Control	−153.075	69.782	0.031	−4467.618	5486.624	0.418
	NRM - Control	62.711	70.929	0.379	−3993.535	5576.812	0.476
	Male - Female	−136.380	57.051	0.019	−4163.224	4485.684	0.356
	Age (1 year diff.)	−4.303	2.104	0.044	62.374	165.447	0.707