Skip to main content
. Author manuscript; available in PMC: 2019 Mar 27.
Published in final edited form as: Cell Rep. 2019 Mar 5;26(10):2805–2817.e9. doi: 10.1016/j.celrep.2019.02.022

Figure 2. NEX–Trio+/− Mice Show Increased Anxiety–like Behavior.

Figure 2.

(A and B) NEX–Trio+/− mice of both sexes spent less time in the center of the open field at an absolute level (A) and when controlling for differences in motility (B) in the open field test (OFT).

(C and D) Male NEX–Trio−/− mice showed no change in anxiety, and female NEX–Trio−/− mice showed decreased anxiety relative to WT littermates at an absolute level (C) and when controlling for differences in motility (D) in the OFT.

(E and G) Representative heatmaps show the time (0 s in purple; >10 s in red) that the mouse spent in each location in the elevated plus maze for NEX–Trio+/− (E) and NEX–Trio−/− (G) mice compared to WT littermates. The asterisks (*) indicate the open arms.

(F and H) Male and female NEX–Trio+/− (F) and male NEX–Trio−/− (H) mice spent less time in the open arms of the elevated plus maze than WT littermates. Female NEX–Trio−/− mice (H) showed no change in open arm time. RM two–way ANOVA with post hoc Bonf MC test identified differences (n = 8–16 littermate pairs).

See also Figures S2, S3, S4, and S5. Data are represented as mean ± SEM (*p < 0.05; **p < 0.01).