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. Author manuscript; available in PMC: 2019 Mar 27.
Published in final edited form as: Cell Rep. 2019 Mar 5;26(10):2805–2817.e9. doi: 10.1016/j.celrep.2019.02.022

Figure 4. Dendritic Arborization Is Reduced in the Motor Cortex of NEX–Trio+/− and NEX–Trio−/− Mice.

Figure 4.

(A and E) Representative dendritic arbor reconstructions are shown for layer 5 pyramidal neurons (L5 PNs) in NEX–Trio+/− (A) and NEX–Trio−/− (E) mice. (B and F) Sholl analysis revealed decreased dendritic arborization on L5 PNs in NEX–Trio+/− (B) and NEX–Trio−/− (F) mice relative to WT controls; the phenotype was more severe in NEX–Trio−/− mice (F). RM two–way ANOVA with post hoc Bonf MC test identified differences (n = 20 neurons from 4 mice per genotype).

(C and G) Apical and basal dendrite length were reduced on L5 PNs in NEX–Trio+/− (C) and NEX–Trio−/− (G) mice relative to WT controls.

(D and H) The numbers of apical and basal branch points were reduced on L5 PNs in NEX–Trio+/− (D) and NEX–Trio−/− (H) mice relative to WT controls. Unpaired t tests identified differences between groups (n = 20 neurons from 4 mice per genotype).

See also Figure S6. Data are represented as mean ± SEM (***p < 0.001; ****p < 0.0001).