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Representative 129Xe ventilation MRI and associated linear-binning and adaptive K-means maps for an older asthmatic subject with high VDP as SNR is progressively degraded. As SNR decreases, linear-binning reports a continuously decreasing VDP caused by noise in the ventilation defect regions being erroneously classified as low-ventilation signal. The adaptive K-means method appears more stable against such misclassification and reports relatively stable VDP down to SNR ~1.8.
