FIGURE 3.

Identification of cluster 6 as the most closely related to the CMV⁺ cluster. (A) t-SNE projection of data from profiled activated cells partitioned into clusters by the K-means clustering algorithm using K = 10. (B) Distribution of Log₂ ratio values obtained by dividing the mean number of transcripts/cell for each gene in the CMV⁺ cluster by the mean number of transcripts/cell for each gene in each of the other nine clusters. The distribution with the Log₂ mean value closest to zero (dotted vertical line) is depicted by a red line. (C) t-SNE projection of data from profiled cells partitioned into clusters by the K-means clustering algorithm using K = 10, and further sub-divided based on marker gene expression. (D) Distribution of Log₂ ratio values, as described in (B), comparing the CMV⁺ cluster to the other 13 clusters. CL, cluster; Erythro, erythrocytes-megakaryocytes; Mono, monocytes; MDDC, monocyte-derived dendritic cells; LC, Langerhans cells; Promyelo, promyelocytes; Act Neut, activated neutrophils; GEMM, colony-forming unit-granulocyte, erythrocyte, monocyte/macrophage, megakaryocyte.