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. 2019 Mar 26;10(2):e00215-19. doi: 10.1128/mBio.00215-19

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Copyright © 2019 Manfiolli et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 8 — Proposed model for the induction of DHN-melanin biosynthesis. The cAMP pathway activates the melanin cluster via protein kinase catalytic subunit 1 (PkaC1), as previously reported (39, 53). The GPCR GprM, which interacts with GpaA, activates the MpkB pathway. MpkB activation affects MpkA, which regulates the DHN-melanin gene cluster. Finally, the transcription factor RlmA directly regulates the expression of the melanin genes by directly binding the pksP promoter (35). Parallel to the expression of the DHN-melanin gene cluster, the activation of MpkB influences the HmgA activity, promoting the accumulation of pyomelanin. ACYA, adenylate cyclase; PKAR, PKA regulatory subunit.