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. 2019 Mar 21;10:543. doi: 10.3389/fimmu.2019.00543

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Copyright © 2019 Karasu, Nilsson, Köhl, Lambris and Huber-Lang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Complement- mediated pathomechanisms in MODS development. Polytrauma, sepsis and hemorrhagic shock cause a critical complement dysregulation, which causes dysfunction in multiple organs. This figure summarizes potential and known pathomechansims for MODS development caused by complement dysregulation. Established complement involvement is highlighted in light green and proposed complement involvement is highlighted in gray.