Table 2.

Overview of observational clinical trials evaluating complement activation after polytrauma and sepsis.

Indication	Endpoint	Participants	Outcome	References
Polytrauma	Inflammatory pattern of complement activation and CRegs on leukocytes	60	Significantly increased serum C3a, C5a, and C5b-9 levels; decreased C5aR expression on neutrophils, which inversely correlated with the clinical outcome; significantly enhanced cC5aR levels, correlating with lethality	NCT00710411
Severe abdominal sepsis	Complement C3 depletion and its association with the down-regulated adaptive immunity	75	C3 depletion was connected to poor prognosis; depletion was associated with coagulopathy and aggravated infection during sepsis	NCT01568853
Polytrauma	Danger response to polytrauma	1000	still recruiting participants	NCT02682550

cC5aR, circulating form of C5aR; CRegs, complement-regulating proteins; CRP, C—reactive protein.