Table 3.
Target | Indication | Primary endpoint | Participants | References |
---|---|---|---|---|
C1 esterase | Trauma or sepsis | Measurement of C1-inhibitor levels, complement concentration and activity, and cytokines; Analysis of neutrophil phenotype and hemodynamic response | Terminated: Study showed limited feasibility |
NCT01275976 |
C1 esterase | Endotoxemia Inflammation MODS |
Measurement of C1-inhibitor levels, complement concentration and activity, Cytokines, and markers of inflammation; Analysis of neutrophil phenotype, and hemodynamic response; Assessment of renal injury |
20 | NCT00785018 |
C5a | Severe sepsis Septic shock |
Evaluation of pharmacodynamic (PD) effects of the C5a antibody | 72 | NCT02246595 |