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. 2019 Mar 21;10:534. doi: 10.3389/fimmu.2019.00534

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Copyright © 2019 Camponeschi, Gerasimcik, Wang, Fredriksson, Chen, Farroni, Thorarinsdottir, Sjökvist Ottsjö, Aranburu, Cardell, Carsetti, Gjertsson, Mårtensson and Grimsholm.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Human unswitched MBCs from patients with RA show an upregulation of LFA-1 subunits. Flow cytometric analysis comparing the expression of αL, β2, α4, and β1 integrin subunits amongst selected B cell populations in PBMCs (A) Patients with RA (B) Comparison between HDs and patients with RA treated with anti-TNF medication or not (C) Comparison between HDs and patients with RA with or w/o anti-TNF medication. Data are pooled from two independent experiments. Error bars show mean +/– SD. An unpaired two-tailed Student t-test was used (^*p < 0.05, ^**p < 0.01, ^***p < 0.001).